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Aztreonam是新型β内酰胺抗生素的第一种——单环β内酰胺抗生素,它有新的单环结构。这种化合物抗需氧革兰氏阴性细菌的活性范围窄,对大多数常见的革兰氏阴性菌β内酰胺酶稳定,不同于许多其它β内酰胺药物,不诱发由染色体传递酶的产生。口服此药不被吸收,需要非肠道使用。用一剂1g进行肌肉注射,一小时平均血清浓度为40mg/L,两小时平均尿浓度为1200mg/L,药物的排泄半存留期为1.3—2小时。
Aztreonam is the first beta-lactam antibiotic - the monocyclic beta-lactam antibiotic, which has a new monocyclic structure. This compound has a narrow range of activity against aerobic gram-negative bacteria and is stable to most common gram-negative bacteria beta-lactamase unlike many other beta-lactam drugs and does not induce the production of chromosomal transfer enzymes. Oral drug is not absorbed, need parenteral use. One dose of 1g intramuscular injection, one hour average serum concentration of 40mg / L, two-hour average urine concentration of 1200mg / L, drug excretion half-life of 1.3-2 hours.