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Ph~1最早见于慢性髓细胞性白血病(以下简称CML)病人,它的发现提供了探索慢粒与急性白血病关系的可能。1979年四月份伦敦白血病研究基金会召开了一次会议讨论Ph~1(+)白血病问题,摘要如下: 现已确定Ph~1为22号染色体长臂脱落移位至9号染色体上,略写为t(9+;22q~-)。Ph~1见于92%的CML,余下者,其它的移位都涉及22号染色体,部分涉及2个以上染色体,但似乎无特殊临床意义。当CML急变时,新的染色体改变可在大约80%的病人发生,包括出现2个Ph~1,额外染色体
Ph~1 was first seen in patients with chronic myelogenous leukemia (CML). Its discovery provides the possibility to explore the relationship between chronic and acute leukemia. In April 1979, the London Leukemia Research Foundation held a meeting to discuss the Ph 1(+) leukemia problem. The summary is as follows: Ph~1 has been identified as the long arm of chromosome 22 that has fallen off to chromosome 9 and is abbreviated as t(9+;22q~-). Ph~1 is found in 92% of CML. In the rest, other translocations involve chromosome 22, and some involve more than two chromosomes, but they seem to have no special clinical significance. When CML changes rapidly, new chromosome changes can occur in approximately 80% of patients, including the appearance of 2 Ph~1, extra chromosomes