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采用PAGE Hb肽链分析技术和Hb常规分析技术,对横县253对(506人)拟婚青年进行地中海贫血筛查(本文简称地贫),共检出各类地贫及异常Hb患者74例,占14.62％。拟婚双方或一方患有地贫者占26.87％(68/253),配对分析显示α/α患者相配占1.58％,α/β患者相配占0.79％。与同时期该地儿童地贫标准监测结果对照,经统计学处理无显著差异,认为在婚检时作地贫筛查是可行的和必要的。
Using PAGE Hb peptide analysis and Hb routine analysis, 74 cases of thalassemia and abnormal Hb were detected in 259 (506) , Accounting for 14.62%. Pairs of patients with or without paroxetine accounted for 26.87% (68/253). Paired analysis showed that α / α patients accounted for 1.58%, α / β patients accounted for 0.79%. Compared with the monitoring results of thalassemia standard in this area, there was no significant difference by statistical analysis. It is feasible and necessary to screen for thalassemia during the premarital examination.