有机溶剂是一种能溶解油脂、蜡、树脂、橡胶和染料等物质的有机化合物,种类多,用途广。有机溶剂所致的危害取决于各化合物的毒性和吸收到体内的量。尽管呼吸道是主要的吸收途径,但亦不容忽视经皮吸收的非局部损害问题。有机溶剂的经皮吸收速度,因化合物不同而异。吸收后毒性的差异亦较大;多以体内代谢产物的增加来评价经皮吸收的有害程度。在 AGGIH 容许浓度表中,对经皮吸收可能引起中毒的一些有害物质均标以“皮”,以示除呼吸道吸入外,还应避免皮肤的直接接触。一般有机溶剂标以“皮”的,芳香烃类有苯、甲苯、二甲苯、异丙苯和α-甲苯乙烯;醇类有甲醇、丙醇、异丙醇、丙烯醇、糠醇、炔丙 Organic solvents are organic compounds that dissolve oils, waxes, resins, rubbers and dyes, and many others. The harm caused by organic solvents depends on the toxicity of each compound and the amount absorbed into the body. Although the respiratory tract is the main route of absorption, non-localized damage to percutaneous absorption should not be overlooked. The transdermal absorption rate of the organic solvent varies depending on the compound. Differences in absorption after toxicity is also greater; more in vivo metabolites to evaluate the harmful degree of percutaneous absorption. In the AGGIH allowable concentration table, some of the harmful substances that may be toxic to percutaneous absorption are labeled “skin” to show that in addition to respiratory tract inhalation, direct skin contact should also be avoided. Common organic solvents marked “skin”, aromatic hydrocarbons are benzene, toluene, xylene, cumene and α-methyl styrene; alcohols are methanol, propanol, isopropanol, propylene alcohol, furfuryl alcohol,