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宫颈癌的传统治疗方式是根治性手术和放射治疗。以往根据宫颈癌的演变过程,浸润癌的高发年龄为50~55岁,且85%以上是鳞状细胞癌,对放射治疗敏感,放射治疗可达到根治的效果。但近年来,宫颈癌发病有明显年轻化趋势,与其他年龄组比较,年轻宫颈癌患者具有显著不同的临床和病理特征,如非鳞癌比例高、淋巴结转移率高和局部临床期别晚等特点。对于这类患者,若单纯手术或放射治疗,不仅5年生存率低,而且术后易复发,放射治疗者会严重影响其卵巢和阴道功能。为了提高局部晚期宫颈癌患者的生存率,减少复发,必须打破宫颈癌的传统治疗模式。如今,随着化学疗法药物的开发利用和疗效的提高,新辅助化学疗法已成为局部晚期宫颈癌患者综合治疗中的重要组成部分,化学疗法后首选手术,正成为治疗中青年宫颈癌患者的发展趁势。
The traditional treatment of cervical cancer is radical surgery and radiotherapy. According to the past, according to the evolution of cervical cancer, the high incidence of invasive cancer is 50 to 55 years old, and more than 85% are squamous cell carcinoma, sensitive to radiation therapy, radiotherapy can achieve radical effect. However, in recent years, the incidence of cervical cancer is significantly younger, and compared with other age groups, young patients with cervical cancer have significantly different clinical and pathological features, such as a high proportion of non-squamous cell carcinomas, high rates of lymph node metastasis, and late local clinical stages Features. For such patients, if surgery alone or radiotherapy, not only 5-year survival rate is low, but also easy to relapse after surgery, radiotherapy will seriously affect their ovarian and vaginal function. In order to improve the survival rate of patients with locally advanced cervical cancer and reduce the recurrence, we must break the traditional treatment of cervical cancer. Now, with the development and utilization of chemotherapeutic drugs and the improvement of efficacy, neoadjuvant chemotherapy has become an important part of the comprehensive treatment for patients with locally advanced cervical cancer. The first choice after chemotherapy is becoming the development of cervical cancer patients who are young and middle-aged Take advantage of.