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目的 :对受到长期、低剂量率照射的我国早期从事医用X线工作者辐射损伤的远期效应进行细胞遗传学观察和评价。方法 :用 4号和 7号全染色体探针和荧光原位杂交技术 ,分析 2 5名早期X线工作者和 10名对照者外周血淋巴细胞染色体畸变 ,并用Giemsa染色验证。结果 :直观地表现出正常靶染色体和多种畸变。X线工作者的易位占其染色体总畸变的 84%;其他各种畸变率分别为插入 (Ins) 1.9%、双着丝粒 (Dic) 4 .5 %、无着丝粒断片 (Ace) 9.7%;X线工作者的染色体易位率和总畸变率均明显高于对照组 (P <0 .0 0 5 )。结论 :早期医用X线工作者外周血淋巴细胞的染色体畸变以易位为主。
OBJECTIVE: To observe and evaluate the long-term, low-dose radiation effects of early effects of radiation injury on medical X-ray workers in China. Methods: The chromosomal aberrations of peripheral blood lymphocytes in 25 early X-ray workers and 10 controls were analyzed by using chromosome 4 and 7 whole chromosome probes and fluorescence in situ hybridization and verified by Giemsa staining. Results: Visualization of normal target chromosomes and multiple aberrations. The translocations of X-ray workers accounted for 84% of the total chromosome aberrations. The other aberration rates were 1.9% for Ins, 4.5% for dicentric (Dic), Ace (Ace) 9.7%. The X-ray workers’ chromosome translocation rate and total aberration rate were significantly higher than those in the control group (P <0.05). Conclusion: The chromosomal aberrations of peripheral blood lymphocytes in early medical X-ray workers are mainly translocations.