某些亲电子药物在代谢过程中有选择地与乏氧细胞分子结合。这些药物是作为乏氧细胞放射敏感物而发展起来的。该技术已被用来识别多细胞球形体和动物肿瘤中的慢性缺氧细胞区。一位面部晚期黑色素瘤病人,在切除其面部巨大的转移性皮下病变前22小时,服用甲硝达唑。组织切片的放射自显影分析表明,放射活性药物密集标记的区域系肿瘤细胞慢性缺 Certain electrophilic drugs selectively bind to hypoxic cellular molecules during metabolic processes. These drugs are developed as hypoxic cell radiation sensitive substances. This technique has been used to identify chronic hypoxic cell areas in multicellular spheroids and animal tumors. A patient with advanced facial melanoma received metronidazole 22 hours before resection of a huge metastatic subcutaneous lesion on her face. Autoradiographic analysis of histological sections revealed that radioactive drug-intensive marker regions are chronically deficient in tumor cells.