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为探讨ｒａｓ基因蛋白Ｐ２１与胃癌生物学行为的关系，应用ＳＰ免疫组化法检测１９８０～１９８９年存档的３３例胃癌及其癌旁组织石蜡包埋标本的ｒａｓ基因产物Ｐ２１的表达情况，并与临床、病理和随访资料进行对比分析，结果显示：①胃癌标本Ｐ２１阳性表达７例（２１．２１％）；癌旁非癌组织的标本中，除１例微弱阳性外，其余均为阴性；②Ｐ２１的阳性表达与病理类型及肿瘤部位无关；③肿瘤浸润深度及有无淋巴结转移与Ｐ２１的阳性表达之间显著相关；④生存不足１年组的Ｐ２１表达阳性率（５０％）明显高于１～５年组（２２．２２％）和５年以上组，生存１～５年组与５年以上组比较，差异也有显著性。表明Ｐ２１的表达与胃癌的浸润、进展和预后有关，提示Ｐ２１的检测有可能成为胃癌预后的有效判断指标，并有指导临床治疗的意义。
To investigate the relationship between the ras gene protein P21 and the biological behavior of gastric cancer, SP immunohistochemistry was used to detect the expression of ras gene product P21 in 33 cases of gastric cancer and paracancerous tissue archived from 1980 to 1989. Clinical, pathological and follow-up data were compared and analyzed. The results showed that: 1 The positive expression of P21 in gastric cancer specimens was found in 7 cases (21.21%); in the specimens adjacent to non-cancerous tissues, except 1 case with weak positive, the others were negative; 2P21 The positive expression was not related to histological type and tumor location. 3 The depth of tumor invasion and lymph node metastasis were significantly correlated with the positive expression of P21; 4 The positive rate of P21 expression (50%) was significantly higher than that of 1 to 1 year group. In the 5-year group (22.22%) and the 5-year-old group, there was a significant difference between the 1- to 5-year group and the 5-year group. It is suggested that the expression of P21 is related to the infiltration, progression and prognosis of gastric cancer, suggesting that the detection of P21 may become an effective index for the prognosis of gastric cancer and has the significance of guiding clinical treatment.