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目的:探讨新疆地区汉族女性人群中HPV感染及基因型的情况和不同年龄HPV感染的分布情况。方法:采用回顾性研究的方法统计分析882例新疆汉族女性HPV感染情况,利用PCR-反向点杂交法为原理的人乳头状瘤病毒分型检测试剂盒对19种基因型的HPV进行分型检测,统计分析不同年龄HPV感染情况。结果:新疆地区汉族女性人群HPV的感染率是21.32%,其中低危型感染、单一高危型感染、混合高危型感染的阳性率分别是5.67%、10.43%和5.22%。在所有亚型中,HPV16型的检出率最高,达20.80%。高危型HPV亚型感染出现频率依次为16、52、58和18型,低危型HPV亚型感染出现频率依次为53、6、66和11型。在所有年龄组,HPV总的感染率及高危型HPV感染率差异均无统计学意义;而对于低危型感染,18~30岁组、51~60岁组和60岁以上年龄组人群感染率明显高于其它年龄组(均P<0.001)。结论:新疆汉族各年龄段妇女人群存在较为普遍的HPV感染且具有地域特点,其中年轻汉族女性低危型HPV感染率较高,应加强该部分人群的HPV认知度,从而预防HPV感染。
Objective: To investigate the prevalence of HPV infection and genotypes and the distribution of HPV infection in different age groups among Han female population in Xinjiang region. Methods: A retrospective study was conducted to analyze the HPV infection of 882 Han women in Xinjiang. HPV genotypes of 19 genotypes were genotyped by PCR-reverse dot blot hybridization Detection, statistical analysis of HPV infection at different ages. Results: The HPV infection rate of Han women in Xinjiang was 21.32%. The positive rates of HPV infection in low-risk type, high-risk type and high-risk type were 5.67%, 10.43% and 5.22% respectively. In all subtypes, HPV16 type the highest detection rate, up to 20.80%. The frequency of high-risk HPV subtype infections were 16,52,58 and 18, and the low-risk HPV subtype infections were 53,6,66 and 11 respectively. In all age groups, there was no significant difference in the total HPV infection rate and the high-risk HPV infection rate. For low-risk infection, the infection rates among 18-30 years old group, 51-60 years old group and 60 years old group Significantly higher than other age groups (all P <0.001). CONCLUSION: There are more common HPV infections among women in all age groups in Xinjiang Han ethnicity. Geographic features are geographical features of young women in Han nationality in Xinjiang. Among them, the prevalence of low-risk type HPV in young Han women is high, and HPV awareness should be strengthened in these groups to prevent HPV infection.