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通脉散为治疗冠心病的纯中药制剂。为了探讨其作用机制而采用结扎家兔冠状动脉复制急性心肌梗塞动物模型（NBT染色法），观察通脉散对心肌梗塞范围和血小板形态及超微结构计量学指标的影响。结果表明：通脉散组的心肌梗塞范围和血小板超微结构指标的改变明显低于维拉帕米组（P＜0．05～0.01），通脉散缩小家兔急性心肌梗塞范围的机制可能与其稳定血小板形态及抑制血小板活性物质的释放有关。
Tongmaisan is a pure Chinese medicine preparation for the treatment of coronary heart disease. In order to investigate its mechanism of action, a rabbit model of coronary artery grafting acute myocardial infarction (NBT staining) was used to observe the effects of Tongmaisan on myocardial infarct size, platelet morphology, and ultrastructure measurement. The results showed that the changes of myocardial infarction range and platelet ultrastructure in Tongmaisan group were significantly lower than those in verapamil group (P<0.05-0.01). The mechanism of Tongmaisan in reducing the scope of acute myocardial infarction in rabbits may be possible. It is related to its stability of platelet morphology and inhibition of the release of platelet active substances.