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复发性口腔溃疡系常见病,在治疗上尚缺乏理想的药物。以往曾使用锡类散、西瓜霜等多种制剂,效果欠佳。根据环丙氟哌酸抗菌作用强,抗菌谱广的特点,我院研制了复方环丙氟哌酸复合膜,此种复合膜选用不溶于口腔温度的 PVA 制成极薄的复盖膜,涂于药膜的一侧,使药膜一面不直接与唾液接触,药物由原来两面释放变为单面释放。为此增加了药膜在用药部位的停留时间,该法制成的药膜经临床105例试用,治愈率在87.6%,总有效率为97%,疗效明显优于普通膜剂。
Recurrent oral ulcer is a common disease, the lack of treatment in the ideal drug. In the past have used tin powder, watermelon cream and other preparations, the effect is not good. According to the antibacterial effect of ciprofloxacin strong antibacterial spectrum of broad characteristics, our hospital developed a compound Ciprofloxacin composite membrane, this kind of composite membrane insoluble in oral temperature PVA made of very thin cover film, coated One side of the membrane, so that the side of the membrane does not directly contact with saliva, the drug from the original release of both sides into a single release. For this reason, the residence time of the medicated film in the medicinal part is increased. The medicinal film prepared by the method is clinically tested in 105 cases with a cure rate of 87.6% and a total effective rate of 97%. The curative effect is obviously superior to that of ordinary film.