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目的探讨进展期胃癌腹膜转移的分子生物学特征及临床病理特征与预后的关系,寻找一种能早期诊断腹膜转移的临床可行方法。方法对193例胃癌患者的分子生物学特征、临床特征及预后进行单因素及相关因素分析,并进行风险评估。结果年龄越低,胃癌腹膜转移的越早;ICAM-1和MMP-2在胃癌发生腹膜转移的患者中高表达;TIMP-1,p53在胃癌发生腹膜转移的患者中表达降低。结论测定ICAM-1,MMP-2,TIMP-1,p53能较好的预测是否发生转移及其预后;血清ICAM-1,TIMP-1,MMP-2,p53作为术前判断胃癌是否发生转移提供了一种可行的方法。
Objective To investigate the molecular biological characteristics and clinicopathological features of peritoneal metastasis of advanced gastric cancer and their relationship with prognosis, and to find a clinical feasible method for early diagnosis of peritoneal metastasis. Methods The molecular biological characteristics, clinical characteristics and prognosis of 193 patients with gastric cancer were analyzed by single factor and related factors, and risk assessment was performed. Results The lower the age, the earlier the peritoneal metastasis of gastric cancer was. ICAM-1 and MMP-2 were overexpressed in patients with peritoneal metastasis of gastric cancer. The expression of TIMP-1 and p53 was decreased in patients with peritoneal metastasis of gastric cancer. Conclusions ICAM-1, MMP-2, TIMP-1 and p53 can be better predictors of metastasis and prognosis. Serum ICAM-1, TIMP-1, MMP-2 and p53 are used as preoperative markers to determine whether metastasis of gastric cancer A viable approach.