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目的：观察个体化模式心理干预对化疗期间大肠癌患者生存质量的影响。方法大肠癌患者随机分为两组，均接受 FOLFOX 方案化疗，观察组接受个体化模式心理干预，对照组接受一般方式心理干预。采用癌症生命质量核心量表、焦虑自评量表、抑郁自评量表对两组患者进行调查及评测。比较不同组患者心理干预前后病人生存质量情况；评估两组的近期客观疗效及化疗副反应。结果两组患者客观近期疗效、3－4度不良反应发生率均无统计学显著性差异。干预前，两组患者生活质量各项得分、SAS 及 SDS 评分差异无统计学意义；干预后，观察组患者的躯体功能、角色功能、情绪功能、认知功能、总健康状况得分高于对照组，疲倦、失眠得分低于对照组。观察组患者的 SAS 及 SDS 评分均明显低于对照组。结论以5阶段病人心理理论为基础的个体化心理干预，能改善化疗期大肠癌患者生活质量、缓解患者焦虑与抑郁状态，其效果优于常规心理干预。“,”Objective To observe the individual mode of psychological intervention on quality of life in patients with colorectal cancer during chemotherapy.Methods Patients with colorec-tal cancer received the FOLFOX chemotherapy were randomly divided into observer group (with individualized mode psychological intervention )and control group (with conventional psychologi-cal intervention).Scale of QLQ -C30,SAS and SDS were used to assess the quality of life of patients with colon cancer.Objective ef icacy and side ef ects of chemotherapy were evaluated for the two groups.Results There were no statistical y significant dif erence between observer group and control group in short -term objective ef ect and grade 3 /4 adverse reaction incidence.There were no statistical y significant dif erence between observer group and control group before psychological intervention in scores of QLQ -C30,SAS and SDS.After psychological intervention, scores of physical function,role function,emotional function,cognitive function and total health status in observer group were higher than that in control group,and scores of fatigue and insomnia in observer group were less than that in control group.After psychological intervention,SAS and SDS scores in observer group were significantly lower than that in control group.Conclusions The individual y psychological intervention based on the five stages -psychological theory can improve the quality of life and relieve anxiety and depressive state of patients with colorectal cancer dur-ing chemotherapy.The ef ect of individual y psychological intervention is superior to conventional psychological intervention.