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目的研究南方汉族人群谷胱甘肽过氧化物酶(GPX-3)基因启动子区-991C/T基因多态性的分布及其与脑梗死的关系。方法检测佛山市南海区第二人民医院神经内科自2011年11月至2015年6月收治的南方地区汉族脑梗死患者112例(病例组)和同期南方地区汉族健康体检者112例(对照组)的GPX-3基因启动子区-991C/T基因多态性,比较两组的一般资料、卒中危险因素及-991C/T基因多态性的分布特点,分析影响脑梗死发生的危险因素。结果与对照组比较,病例组高血压病史、血脂、尿酸、血同型半胱氨酸、血糖水平有明显差异(P<0.01),-991C/T TT基因型频率及T等位基因频率均较高,差异有统计学意义(P<0.05)。结论中国南方地区汉族人群GPX-3基因启动子区-991C/T位点存在多态性,TT基因型或为脑梗死的易感基因型。
Objective To investigate the distribution of -991C / T polymorphism in glutathione peroxidase (GPX-3) gene promoter region and its relationship with cerebral infarction in South Han Chinese population. Methods 112 cases (case group) of Han cerebral infarction and 112 healthy control subjects (control group) of Han nationality in South China from November 2011 to June 2015 in Nanhai District of Foshan City were enrolled in this study. The polymorphism of -991C / T gene in GPX-3 promoter region was analyzed. The general characteristics of the two groups, the risk factors of stroke and the distribution of -991C / T polymorphism were compared, and the risk factors influencing the occurrence of cerebral infarction were analyzed. Results Compared with the control group, the history of hypertension, serum lipids, uric acid, blood homocysteine, and blood glucose levels were significantly different (P <0.01). The frequencies of genotype 991C / T TT and T allele High, the difference was statistically significant (P <0.05). Conclusions There is a polymorphism in the -991C / T locus of GPX-3 gene promoter region in the southern Chinese Han population. TT genotypes are susceptible genotypes of cerebral infarction.