核酶具有特异识别和切割靶 RNA的特点 ,从而可以抑制一些特异基因产物的表达 ,而 型内含子核酶 ,不但具有剪切功能 ,而且可以进行顺式剪接及反式剪接。随着人们对 型内含子核酶的功能结构也有了进一步认识 ,相继用 型内含子核酶对 p5 3突变 m RNA及镰形红细胞贫血等遗传性疾病致病基因 m RNA的修复做了大量的研究 ,并取得了一定的成果 Ribozymes have the characteristics of specific recognition and cleavage of target RNA, which can inhibit the expression of some specific gene products, while intron ribozyme not only has the function of shearing, but also can perform cis-splicing and trans-splicing. As people have further understanding of the functional structure of intron ribozymes, they have used intron ribozymes to repair the m RNA of pathogenic genes such as p35 mutant m RNA and sickle cell anemia A lot of research, and achieved some results