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目的探讨地屈孕酮与绒毛膜促性腺激素对先兆流产的价值。方法 100例先兆流产患者,随机分为研究组和对照组,各50例。对照组采用地屈孕酮进行治疗,研究组采用地屈孕酮与绒毛膜促性腺激素联合治疗,对比两组患者孕次、习惯性流产发生率及治疗前后血清β-人绒毛膜促性腺激素(β-HCG)、孕激素水平和妊娠成功率、早产率、流产率、新生儿体重。结果两组患者孕次、习惯性流产发生率比较差异无统计学意义(P>0.05)。治疗前两组血清β-HCG、孕激素比较差异无统计学意义(P>0.05);治疗后研究组血清β-HCG为(8521.4±2143.4)U/L、孕激素水平为(29.5±6.2)mmol/L,均高于对照组的(6126.8±2958.4)U/L、(26.4±5.8)mmol/L,差异有统计学意义(P<0.05)。研究组妊娠成功率、早产率、流产率及新生儿体重均优于对照组,差异有统计学意义(P<0.05)。结论地屈孕酮联合绒毛膜促性腺激素对先兆流产治疗疗效肯定,能够提高妊娠成功率,减少早产率、流产率。
Objective To investigate the value of dydrogesterone and chorionic gonadotropin on threatened abortion. Methods 100 cases of threatened abortion were randomly divided into study group and control group, 50 cases each. The control group was treated with dydrogesterone. The study group was treated with dydrogesterone and chorionic gonadotropin. The incidence of pregnancy-induced and habitual miscarriage and the serum levels of β-human chorionic gonadotropin (β-HCG), progesterone level and success rate of pregnancy, premature birth rate, abortion rate, newborn weight. Results There was no significant difference in the incidence of habitual abortion between the two groups (P> 0.05). Serum levels of β-HCG and progesterone in the two groups were not significantly different (P> 0.05). The levels of serum β-HCG in the study group were (8521.4 ± 2143.4) U / L and the progesterone level was (29.5 ± 6.2) mmol / L, which was significantly higher than that of the control group (6126.8 ± 2958.4 U / L, (26.4 ± 5.8) mmol / L, P <0.05). The study group pregnancy success rate, premature birth rate, abortion rate and neonatal weight were better than the control group, the difference was statistically significant (P <0.05). Conclusions Dydrogesterone combined with chorionic gonadotrophin is effective in the treatment of threatened abortion, which can improve the success rate of pregnancy, reduce the rate of preterm birth and abortion.