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人胎球蛋白主要由肝脏分泌,属于胎球蛋白族的人血浆糖蛋白。最新研究发现,此蛋白为胰岛素受体酪氨酸激酶天然的抑制剂,同时也是天然的钙沉积抑制剂,其基因多态性致血浆人胎球蛋白水平变化参与代谢综合征和动脉粥样硬化的发生、发展。本文对其致病关系研究进展做一综述。
Human fetal globulin is mainly secreted by the liver and belongs to the human plasma glycoprotein of the fetuin family. The latest study found that this protein is a natural inhibitor of insulin receptor tyrosine kinase, but also a natural inhibitor of calcium deposition, the gene polymorphism in plasma human fetal globulin levels involved in metabolic syndrome and atherosclerosis The occurrence and development. This article reviews the progress of the study on the relationship between pathogenicity.