论文部分内容阅读
目的 :观察和比较冠心苏合软胶囊和冠心苏合丸的药理作用。方法 :用垂体后叶素致大鼠心肌缺血后 ,测定乳酸脱氢酶 (LDH)活性、小鼠整体缺氧及异丙肾上腺素致缺氧的保护作用 ;给大鼠ig高脂乳剂造成高脂模型 ,观察药物的调脂作用和血流变学指标的变化情况。结果 :冠心苏合软胶囊可对抗脑垂体后叶素引起的大鼠急性心肌缺血 ,显著改善缺血心电图J点上抬的变化 ,降低血清乳酸脱氢酶活性 ;提高小鼠耐缺氧能力 ,延长小鼠缺氧死亡时间。但对高脂模型大鼠的血流变学特性无显著影响 ,对其高血脂有改善的作用趋势。结论 :冠心苏合软胶囊抗心肌缺血、缺氧 ,作用略优于冠心苏合丸。
Objective : To observe and compare the pharmacological effects of Guanxin Suhe soft capsule and Guanxin Suhe Wan. METHODS: The protective effect of lactate dehydrogenase (LDH) activity, mouse hypoxia, and hypoxia induced by isoproterenol were measured after myocardial ischemia in rats induced by pituitrin. Hyperlipidemia was induced in rat ig high fat emulsion. The model was used to observe the lipid-regulating effect of the drug and the changes of the hemorheology index. RESULTS: Guanxin Suhe soft capsule can prevent acute myocardial ischemia induced by pituitrin in rats, significantly improve the change of J-point elevation in ischemic electrocardiogram, and decrease the activity of serum lactate dehydrogenase; increase the tolerance to hypoxia in mice. Ability to prolong mouse hypoxia death time. However, there was no significant effect on the blood rheology of high-fat model rats, and there was a tendency for its high blood lipids to improve. Conclusion : Guanxin Suhe soft capsule is anti-myocardial ischemia and hypoxia. It is slightly better than Guanxin Suhe Pill.