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目的探讨红芪多糖(HPS)对实验性大鼠糖尿病胰岛素抵抗肿瘤坏死因子-α(TNF-α)的影响。方法随机抽取正常大鼠为正常对照组,剩余大鼠使用高脂高糖饲料和注射小剂量链脲佐菌素诱导糖尿病胰岛素抵抗大鼠模型。造模成功的大鼠随机分为模型组、二甲双胍组、HPS小剂量组、HPS大剂量组,并分别予以0.9%NaCl溶液、二甲双胍、HPS大小剂量灌胃治疗4周。检测各组大鼠空腹血糖(FPG)、血清胰岛素(INS)、胰岛素敏感性指数(ISI)、血脂、血清TNF-α。结果与空白组比较,模型组FPG、INS、TG、TC、TNF-α升高,HDL-C、ISI降低,差异有统计学意义(P<0.01)。与模型组比较,HPS大、小剂量组以及二甲双胍组,FPG、INS、TG、TC、TNF-α降低;HDL-C、ISI升高,且差异有统计学意义(P<0.05,P<0.01)。结论 HPS可改善糖尿病胰岛素抵抗大鼠血清TNF-α及其相关指标。
Objective To investigate the effect of HsPS on insulin resistance of tumor necrosis factor-α (TNF-α) in experimental diabetic rats. Methods Normal rats were randomly selected as the normal control group. The remaining rats were induced with high-fat and high-sucrose diet and streptozotocin (STZ) to induce insulin resistance in diabetic rats. The successful model rats were randomly divided into model group, metformin group, HPS low dose group and HPS high dose group, and treated with 0.9% NaCl solution, metformin and HPS respectively for 4 weeks. Fasting plasma glucose (FPG), serum insulin (INS), insulin sensitivity index (ISI), blood lipid and serum TNF-α were detected in each group. Results Compared with the blank group, the levels of FPG, INS, TG, TC, TNF-α in the model group increased, while the levels of HDL-C and ISI decreased in the model group (P <0.01). Compared with the model group, the levels of FPG, INS, TG, TC and TNF-α in the HPS group and the low-dose group and the metformin group were decreased, while the levels of HDL-C and ISI in the model group were significantly higher than those in the model group (P <0.05, P <0.01) ). Conclusion HPS can improve serum TNF-α and its related indicators in diabetic insulin resistance rats.