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运用对多种神经递质受体有选择性的放射性标记配基以及定量的放射性自显影方法,对中枢神经系统和外周各种因素引起的呕吐反射的神经通路和受体亚型有了更深入的了解。在脑内与呕吐反射有关系的多个部位检测到胆碱能、多巴胺、组胺以及5-HT_3受体,并提出能抑制这些神经递质受体亚型的止吐药作用的理论基础。而对地塞米松和大麻样物质的止吐
Using radiolabeled ligands that are selective for a variety of neurotransmitter receptors and quantitative autoradiography, the neural pathways and receptor subtypes of vomiting and reflex caused by various factors in the central nervous system and periphery are further in-depth Understand. Cholinergic, dopamine, histamine, and 5-HT 3 receptors were detected in several parts of the brain associated with vomiting reflexes and suggested the rationale for the antiemetic effects of these neurotransmitter receptor subtypes. And for dexamethasone and cannabis-like substances antiemetic