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目的 :研究常见心血管疾病中血浆内线粒体偶联因子 6 (mitochondrialcouplingfactor 6 ,CF6 )含量的变化 ,以探讨CF6在其发病中的意义。方法 :放射免疫分析检测血浆CF6的含量 (pg/ml)。结果 :正常健康人群血浆CF6含量为 2 10 5± 33 7pg/ml。原发性高血压患者为 30 7 5± 95 5pg/ml,急性心肌梗塞患者为 36 4 5±10 5 1,心力衰竭患者为 35 1 2± 10 4 6 ;睡眠呼吸暂停综合征患者为 35 1 9± 87 1,原发性高血压伴糖尿病患者为4 6 6 4± 136 3,p<0 0 1,与正常人比较均明显升高 (均p <0 0 1或p<0 0 5 ) ;稳定性心绞痛患者为 2 6 6 3± 6 9 3,心律失常患者为 2 5 8 8± 80 1,有上升趋势 ,但无统计学明显差异 (p >0 0 5 ) ,肺动脉高压患者降低 (15 9 3±12 2 8,p>0 0 5 )。结论 :原发性高血压、急性心肌梗塞、心力衰竭、睡眠呼吸暂停综合征患者血浆CF6含量明显升高 ,并与病情严重程度有关 ,提示CF6可能在其病理生理过程中发挥着重要的作用 ,对于变化的机制及其意义有待于深入研究。
Objective: To study the change of plasma mitochondrial coupling factor 6 (CF6) content in common cardiovascular diseases to explore the significance of CF6 in its pathogenesis. Methods: Radioimmunoassay was used to detect plasma levels of CF6 (pg / ml). Results: The plasma levels of CF6 in normal healthy subjects were 2 105 ± 33 7 pg / ml. Patients with essential hypertension were 30 7 5 ± 95 5 pg / ml, 36 4 5 ± 10 5 for acute myocardial infarction, 35 1 2 ± 10 4 6 for heart failure and 35 1 for sleep apnea syndrome 9 ± 87 1, patients with essential hypertension with diabetes were 4 6 6 4 ± 136 3, p <0.01, which were all significantly higher than those in normal controls (all p <0.01 or p <0.05) ; Patients with stable angina pectoris were 2643 ± 693 and patients with arrhythmia were 2588 ± 801, with an upward trend but no statistically significant difference (p> 0.05), patients with pulmonary hypertension reduced 15 9 3 ± 12 2 8, p> 0 0 5). Conclusion: The plasma CF6 levels in patients with essential hypertension, acute myocardial infarction, heart failure and sleep apnea syndrome were significantly increased, which were related to the severity of the disease, suggesting that CF6 may play an important role in the pathophysiological process, The mechanism of change and its significance needs further study.