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目的探讨维生素D对反复呼吸道感染(RRI)患儿血清25-羟维生素D_3[25-(OH)D_3]和免疫球蛋白的影响。方法选取2013年2月至2015年7月在铜仁妇女儿童医院治疗的RRI患儿195例为研究对象,将患者随机分为观察组(102例)和对照组(93例),对照组给予常规治疗,观察组在对照组治疗的基础上口服维生素D制剂,同时选取健康儿童60例为健康组,检测各组25-(OH)D_3和免疫球蛋白水平(Ig A、Ig M和Ig G)。结果观察组和对照组治疗后呼吸道感染次数较治疗前明显降低(P<0.05);观察组治疗后呼吸道感染次数明显低于对照组(P<0.05);观察组和对照组治疗前25-(OH)D_3、Ig A、Ig M和Ig G明显低于健康组(P<0.05);观察组治疗后25-(OH)D_3、Ig A、Ig M和Ig G明显较治疗前升高,同时高于对照组治疗后(P<0.05);对照组治疗前后25-(OH)D_3、Ig A、Ig M和Ig G比较,差异无统计学意义(P<0.05);观察组治疗前后25-(OH)D_3变化值与Ig A、Ig M和Ig G变化值呈正相关(r=0.850、0.580、0.691,均P<0.05)。结论RRI患儿血清25-(OH)D_3及免疫球蛋白水平有所降低,补充维生素D能调节机体免疫功能,提高治疗疗效。
Objective To investigate the effect of vitamin D on serum 25-hydroxyvitamin D 3 [25- (OH) D 3] and immunoglobulin in children with recurrent respiratory tract infections (RRI). Methods A total of 195 children with RRI who were treated in Tongren Women and Children’s Hospital from February 2013 to July 2015 were selected as study subjects. The patients were randomly divided into observation group (102 cases) and control group (93 cases), and control group The treatment group and the observation group received oral vitamin D preparation on the basis of the control group. Meanwhile, 60 healthy children were selected as the healthy group. The levels of 25- (OH) D 3 and immunoglobulin (Ig A, Ig M and Ig G) . Results The number of respiratory infections in observation group and control group was significantly lower than that before treatment (P <0.05), and the number of respiratory infections in observation group was significantly lower than that in control group (P <0.05). In observation group and control group, OH) D 3, Ig A, Ig M and Ig G were significantly lower than those in healthy group (P <0.05). The levels of 25- (OH) D 3, Ig A, Ig M and Ig G in the observation group were significantly higher than those before treatment (P0.05) .The difference of 25- (OH) D 3, Ig A, Ig M and Ig G in the control group before and after treatment was not statistically significant (P0.05) (OH) D 3 was positively correlated with the changes of Ig A, Ig M and Ig G (r = 0.850, 0.580, 0.691, all P <0.05). Conclusion Serum 25- (OH) D 3 and immunoglobulin levels are decreased in RRI children. Vitamin D supplementation can regulate immune function and improve therapeutic efficacy.