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目的 探讨ER和p53蛋白表达与ESCC的临床病理关系。方法 应用免疫组织化学方法检测了ESCC中ER和p53蛋白的表达。结果 4 7例ESCC中 ,ER阳性者 19例 ,其表达率为4 0 4 % (19 4 7) ;生存期大于 5年组与生存期小于 5年组相比 ,具有显著性差异 (P <0 0 5) ;p53蛋白表达者 2 9例 ,表达率为 6 1 7% (2 9 4 7) ;其阳性率在淋巴结有无转移 ,病人生存期长短之间存在明显差异。ER阳性ESCC的p53蛋白阳性表达率高于ER阴性ESCC ,具有统计学差异。结论 ER阳性的食管癌与p53蛋白表达密切相关。ER及p53蛋白的表达与ESCC的预后密切相关。
Objective To investigate the clinicopathological relationship between the expression of ER and p53 protein and ESCC. Methods The expression of ER and p53 protein in ESCC was detected by immunohistochemistry. Results Of the 47 ESCC patients, 19 were positive for ER, and the expression rate was 4 0 4 % (19 47). The survival period was greater than 5 years and the difference was significant (P < 0 0 5); p53 protein expression in 29 cases, the expression rate of 61.7% (2 9 47); the positive rate in the lymph node metastasis, the length of survival of patients there is a significant difference. The positive expression rate of p53 protein in ER-positive ESCC was higher than that in ER-negative ESCC. Conclusion ER-positive esophageal cancer is closely related to the expression of p53 protein. The expression of ER and p53 protein is closely related to the prognosis of ESCC.