弥漫性细支气管炎(DPB)是以呼吸细支气管病变为主,具有明显的呼吸困难和特殊的胸部X 线表现的一种独立疾病。80～83年日本厚生省进行了全国性调查,并制定出诊断指南。本病的诊断以症状、胸部体征及肺功能检查为主,经支气管肺活检(TBLB)的开展,提高了对本病从病理学角度作最后诊断的可能性。患者早期仅有轻咳,偶有呼吸困难,不久在疲劳后感气急,多伴有喘鸣。反复感染后,炎症波及中小支气管,每日痰量增加至数十毫升,且呈脓性。咳嗽、咯痰、呼吸困难均以午前明显,如痰在午前充分排尽,则午后轻快。早期病原菌多为流感、肺炎菌等,后期多并发绿脓菌感染,则病情加重,顽固不愈,预后不 Diffuse bronchiolitis (DPB) is an independent disease characterized by respiratory bronchioles, with marked dyspnea and special chest X-ray findings. 80 to 83 years Japan’s Ministry of Health conducted a national survey and developed diagnostic guidelines. The diagnosis of the disease to symptoms, chest signs and pulmonary function tests based on the development of bronchial lung biopsy (TBLB), raised the pathological diagnosis of the disease for the possibility of the final. Early only mild cough, occasional breathing difficulties, shortly after the feeling of irritability, often accompanied by wheezing. Repeated infection, inflammation spread to the small bronchi, daily sputum volume increased to tens of ml, and was purulent. Cough, expectoration, dyspnea were significantly before noon, such as sputum in the exhaust before the full exhaust, the afternoon light. Early pathogenic bacteria are mostly flu, pneumonia, etc., the late multiple concurrent pyocyanin, the disease aggravated, stubborn, the prognosis is not