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目的:探讨补肾利湿法对动物痛风性关节炎防治作用及其作用机制。方法:采用尿酸钠联合氧嗪酸钾致痛风性关节炎模型,测定大鼠关节肿胀度,观察大鼠步态,测定大鼠血清尿酸水平。结果:补肾利湿法处方中药具有明显抑制大鼠足肿胀的作用,改善大鼠步态,并能降低大鼠血清尿酸水平。结论:补肾利湿法有明显的防治痛风性关节炎的作用,值得进一步研究。
Objective: To explore the preventive and therapeutic effects of tonifying kidney and dampness on animal gouty arthritis and its mechanism. Methods: Gouty arthritis model was induced by sodium urate combined with oteracil potassium. The degree of swelling in the joints was measured. The gait of the rats was observed. The level of serum uric acid in the rats was measured. Results: Prescriptions for invigorating the kidney and dampness could obviously inhibit the foot swelling in rats, improve the gait in rats and decrease the serum uric acid level in rats. Conclusion: The method of tonifying the kidney and dampness obviously has the effect of preventing and treating gouty arthritis, which deserves further study.