自从1949年Cade首先发现碳酸锂能治疗躁狂症以来,锂盐一直是治疗躁狂症和双相情感障碍的首选用药。它对急性躁狂发作和抑郁发作均有效,不会引起躁狂转相,长期使用能够预防复发,并能降低患者自杀率。因锂盐不与血浆和组织蛋白结合,主要通过肾脏排泄,其毒性大,治疗窗狭窄,中毒现 Lithium salts have been the treatment of mania and bipolar disorder since Cade first discovered that lithium carbonate was able to treat mania in 1949. It is effective for acute manic episodes and depressive episodes, does not cause manic phase, long-term use can prevent recurrence, and can reduce suicide rates. Lithium salt is not combined with plasma and tissue protein, mainly excreted through the kidneys, its toxicity, therapeutic window is narrow, poisoning is