由蚊媒传播的疾病,如疟疾、登革热、流行性乙型脑炎、黄热病等已严重影响人类健康,但至今尚无有效的防治方法。沃尔巴克氏体是在自然界中广泛存在的、经母系遗传的共生菌,可诱导蚊群产生胞质不相容。迄今为止,胞质不相容的分子机制尚未明确,但“锁-钥匙”模型(lock and key model)、“移除-归还”模型(titration-restitution model)和“减速”模型(slow-motion model)可在一定程度上解释胞质不相容现象。胞质不相容产生的整个过程极为复杂,是多种因子共同作用的结果。该文就胞质不相容的模型及分子机制进行综述。 Mosquito-borne diseases such as malaria, dengue fever, Japanese encephalitis, yellow fever and other diseases have seriously affected human health, but so far no effective prevention and treatment methods have been found. Wolbachia is widely found in nature and the maternal-derived commensal bacteria induce cytosolic incompatibility in mosquitoes. So far, the molecular mechanisms of cytoplasmic incompatibility have not been clarified, but the lock and key model, the titration-restitution model, and the deceleration- The “slow-motion model” explains to a certain extent the cytoplasmic incompatibility. The entire process of cytoplasmic incompatibility is extremely complex and is the result of a combination of multiple factors. This article reviews the models and molecular mechanisms of cytoplasmic incompatibility.