采用喷雾干燥技术因溶剂蒸发迅速,已广泛用于加工对热敏感的食品、化学品、药品干燥的有效方法。液态微滴经化学反应直接制备固体微粒为近年来新技术之一。苯巴比妥与茶碱合用,它有抑制茶碱对中枢神经的兴奋作用。喷雾干燥法直接制备可压性茶碱—苯巴比妥固体微粒的混合物,可避免吸收慢和生物利用度差的缺点。 Spray drying technology due to the rapid evaporation of solvents, has been widely used in the processing of heat-sensitive foods, chemicals, pharmaceuticals effective method of drying. Liquid droplets prepared by chemical reaction of solid particles in recent years, one of the new technologies. Phenobarbital and theophylline combined, it inhibits the theophylline on the central nervous excitement. The direct preparation of a mixture of compressible theophylline-phenobarbital solid particles by spray drying avoids the disadvantages of slow absorption and poor bioavailability.