肿瘤坏死因子(TNF)的生物学作用正在不断增加。据得克萨斯大学和基因技术公司的研究人员称,TNF除了杀伤瘤细胞以及可能与恶液素相同,即能引起癌症病人消瘦外,TNF还在体外刺激骨分解和吸收,并抑制新骨形成。利用骨培养的方法,科学家们发现,以前称为淋巴毒素的TNF-α和TNF-β均可增加使骨细胞间钙化物已呈分解的细胞数量,减少含矿物质的骨基质并抑制了骨细胞产生骨胶原。上述实验只是在细胞培养中进行的,但其 The biological effects of tumor necrosis factor (TNF) are increasing. According to researchers at the University of Texas and Genentech, TNF, in addition to killing tumor cells and possibly the same as xerosine, can cause weight loss in cancer patients, TNF also stimulates bone breakdown and absorption in vitro and inhibits new bone formation. Using bone culture methods, the scientists found that both TNF-α and TNF-β, formerly known as lymphotoxins, increased the number of cells that decomposed calcium in bone cells, reduced the mineral-containing bone matrix and inhibited bone. Cells produce collagen. The above experiment was only performed in cell culture, but it