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目的观察脑出血患者白细胞介素-1β(IL-1β)、细胞间粘附分子-1(ICAM-1)和肿瘤坏死因子-α(TNF-α)含量的变化及头部亚低温对其的影响。方法 86例脑出血患者根据是否加用头部亚低温治疗分为头部亚低温组(45例)和对照组(41例),采用酶联免疫吸附法(ELISA)测定两组患者治疗前及治疗后7d血清1L-1β、ICAM-1、TNF-α含量,并与正常组(30例)进行比较。结果头部亚低温组和对照组治疗前1L-1β、ICAM-1、TNF-α明显升高,与正常组比较差异均具有显著性(P<0.01);治疗前头部低温组和对照组间1L-1β、ICAM-1、TNF-α差异均无显著性(P>0.05);治疗后7d,头部亚低温组1L-1β、ICAM-1、TNF-α较治疗前明显降低(P<0.05),对照组降低不明显(P>0.05),头部亚低温组与对照组比较差异均具有显著性(P<0.01)。结论脑出血患者早期血清1L-1β、ICAM-1、TNF-α含量明显升高,头部亚低温组可有效降低其含量。
Objective To observe the changes of interleukin-1β (IL-1β), intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor-α (TNF- influences. Methods Eighty-six patients with cerebral hemorrhage were divided into two groups according to whether the head hypothermia was given or not: 45 cases in the head hypothermia group and 41 cases in the control group. Enzyme-linked immunosorbent assay (ELISA) The levels of serum 1L-1β, ICAM-1 and TNF-α at 7 days after treatment were compared with those in normal group (30 cases). Results The levels of 1L-1β, ICAM-1 and TNF-α in the head hypothermia group and the control group before treatment were significantly higher than those in the normal group (P <0.01). Before treatment, the head hypothermia group and the control group 1L-1β, ICAM-1 and TNF-α in the head hypothermia group were significantly lower than those before treatment (P> 0.05) <0.05), while there was no significant difference in the control group (P> 0.05). There was significant difference between the head hypothermia group and the control group (P <0.01). Conclusions The levels of serum 1L-1β, ICAM-1 and TNF-α in early stage of cerebral hemorrhage are significantly higher than those in the mild hypothermia group.