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1978年~1980年作者用人白细胞干扰素治疗21例多发性骨髓病(MM)病人。所用制剂为每 mg 蛋白含0.2~1.0×10~6U 干扰素活性物质。所有病人均诊断明确,骨髓内浆细胞明显增生,血清和/或尿中有大量单株蜂瘤蛋白。病人平均年龄57(42~76)岁,男性占57%。21例中12例以前未经治疗,5例曾用烷化剂一皮质激素联合化疗有效后又复发,4例曾经化疗无效。全部病人均用人白细胞干扰素肌注,每天用量至少3×10~6U,疗程为3个月以上。有几个病人短期用量增至6×10~6和9×10~6U 以便了解病人的耐受量和血清中干扰素浓度的变化。21例中5例有效(其中3
From 1978 to 1980, the authors used human leukocyte interferon to treat 21 patients with multiple myelopathy (MM). The preparation used is 0.2 ~ 1.0 × 10 ~ 6U interferon active substance per mg of protein. All patients were diagnosed clearly marked proliferation of bone marrow plasma cells, serum and / or urine in a large number of single oncolytic protein. The average age of patients 57 (42 to 76) years of age, men 57%. Twelve of the 21 patients were untreated before, 5 had recurred with alkylating agent-corticosteroid plus chemotherapy, and 4 had failed chemotherapy. All patients with human leukocyte interferon intramuscular injection, daily dosage of at least 3 × 10 ~ 6U, treatment for more than 3 months. Several patients increased the short-term dose to 6 × 10 -6 and 9 × 10 -6 U in order to understand patient tolerance and serum interferon concentrations. Of the 21 cases, 5 were effective (3 of them)