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目的:探讨口服降糖药联合甘精胰岛素治疗门诊2型糖尿病患者的临床疗效。方法:选取我院门诊部在2011年1月至2013年10月收治的2型糖尿病患者60例,将所有患者随机分为观察组和对照组,对照组给予口服降糖药治疗,观察组在口服降糖药治疗的基础上联合应用甘精胰岛素治疗,比较两组治疗效果。结果:两组患者在治疗8周后的FBG、2hBG和HbA1c指标均较治疗前明显下降(P<0.05),且观察组变化更为显著(P<0.05);观察组血糖达标时间明显短于对照组(P<0.05);两组低血糖发生率比较无明显差异(P>0.05)。结论:在口服降糖药的基础上联合应用甘精胰岛素治疗2型糖尿病患者疗效显著,且具有平稳、持久、无峰值等特点,值得临床推广。
Objective: To investigate the clinical efficacy of oral hypoglycemic agents combined with insulin glargine in the treatment of outpatients with type 2 diabetes mellitus. Methods: Sixty patients with type 2 diabetes mellitus were selected from outpatient department of our hospital from January 2011 to October 2013. All the patients were randomly divided into observation group and control group. The control group was treated with oral hypoglycemic agents. The observation group Oral hypoglycemic agents based on the combination of insulin glargine treatment, the two groups were compared. Results: The indexes of FBG, 2hBG and HbA1c in two groups after treatment for 8 weeks were significantly lower than those before treatment (P <0.05), and the changes in the observation group were more significant (P <0.05); the observation group’s blood glucose time was significantly shorter (P <0.05). The incidence of hypoglycemia was no significant difference between the two groups (P> 0.05). Conclusion: The combination of oral ghrelin and insulin glargine treatment of type 2 diabetes patients with significant effect, and has a stable, durable, peak-free, worthy of clinical promotion.