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一九六四年发现天疱疮血清中含有可与表抗原直接起反应的自家抗体,而抗原位于最早期病理改变处。此后,对人类的水疱大疮性疾病免疫病理学机转进行过深入的研究。水疱大疮性皮肤病包括:天疱疮、大疱性类天疱疮、瘢痕性类天疱抢、阴部疱疹、多形红斑、疱疹样皮炎。由于对这些疾病的免疫病理学机能有了深刻的理解,而且对其合理的治疗方面也取得了较好的进展,因而加速了对这些疾病的病理学方面的研究,并对免疫病理学方面问题能更深入地思考(自体抗体、免疫复合物、细胞中介物质如何参与局部免疫损伤的)。虽然上述大疱性疾病较少见,但可用来更好地对这些免疫中介性疾病深入地进行基础方面的研究。
In 1964, pemphigus sera were found to contain autoantibodies that react directly with the epitope antigens, whereas the antigens are located at the earliest pathological changes. Since then, an extensive study has been conducted on the immunopathological mechanisms of human blistering diseases. Blisters Obese skin diseases include: pemphigus, bullous pemphigoid, cicatricial bullpen grab, genital herpes, erythema multiforme, herpetic dermatitis. The profound understanding of the immunopathological features of these diseases and the good progress they have made in the rational treatment of these diseases have accelerated the study of the pathology of these diseases and have highlighted the immunopathological aspects Think more deeply (how autoantibodies, immune complexes, and cellular mediators participate in local immune damage). Although the above-mentioned bullous diseases are rare, they can be used to better conduct fundamental research on these immune-mediated diseases.