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观察 2型糖尿病血中胰岛素样生长因子 - 1(IGF- 1)水平与糖尿病肾病的关系。方法 :用 EL ISA法对5 7例 2型糖尿病患者血中 IGF- 1浓度进行测定。结果 :12型糖尿病患者血 IGF- 1水平显著低于正常人 (P<0 .0 1)。糖尿病肾病组血 IGF- 1水平显著高于单纯糖尿病组 (P<0 .0 1) ;2 IGF- 1与 Ccr呈正相关 (r=0 .36 8,P<0 .0 5 ) ;3 IGF- 1与FPG呈负相关 (r=- 0 .45 738,P<0 .0 5 )。结论 :2型糖尿病合并糖尿病肾病患者血 IGF- 1水平高于单纯糖尿病患者。IGF-1可能参与糖尿病肾病的发生和发展。
To observe the relationship between the level of insulin-like growth factor-1 (IGF-1) and diabetic nephropathy in type 2 diabetic patients. Methods: The blood levels of IGF-1 in 57 patients with type 2 diabetes mellitus were measured by ELISA. Results: The level of IGF-1 in type 2 diabetes patients was significantly lower than that in normal people (P <0.01). IGF-1 levels in diabetic nephropathy group were significantly higher than those in simple diabetic group (P <0.01); 2 IGF-1 was positively correlated with Ccr (r = 0.368, P <0.05); 3 IGF- 1 was negatively correlated with FPG (r = - 0.45 738, P <0.05). Conclusion: The level of IGF-1 in type 2 diabetic patients with diabetic nephropathy is higher than that in simple diabetic patients. IGF-1 may be involved in the occurrence and development of diabetic nephropathy.