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利福平的特点是对细胞内存在的细菌,包括静止期高度稳定的菌群,具有高度抗菌活性。这对于杀灭实验动物体内结核杆菌具有重要意义。静脉注射利福平使血浓度较口服给药高,是迅速获得疗效的原因。本文目的在于对比评价利福平静脉注射与胃肠内给药治疗用0.1mgBovinus-8结核菌株高毒培养物所致之兔实验性血行播散性结核的疗效。不予治疗的对照组兔在实验性感染1.5～2月后死于进展性结核病,于肺内可见小结节性病变相互融合成的聚合体,于其它内脏器官可见粟粒大结节排列成的稠密网状。胃肠
Rifampicin is characterized by its high degree of antibacterial activity against bacteria present in the cells, including highly stable colonies at rest. This is important for killing Mycobacterium tuberculosis in experimental animals. Intravenous injection of rifampin to blood concentrations higher than oral administration, is the reason for the rapid access to efficacy. The purpose of this paper is to compare the efficacy of rifampicin and gastrointestinal administration in the treatment of experimental hematogenous disseminated tuberculosis in rabbits caused by high virulent cultures of 0.1 mg Bovinus-8 tuberculosis strain. Control untreated rabbits died of progressive tuberculosis after 1.5 to 2 months of experimental infection, and aggregates of small nodular lesions were found in the lungs. In other internal organs, large nodules were arranged Dense mesh. Gastrointestinal