脑白质损伤(white matter injury,WMI)是早产儿脑损伤最常见的类型,在美国,每年约有65 000名极低出生体重儿出生,其WMI发生率高达50%,其中有5%~10%发生脑瘫,25%~50%遗留认知、行为、注意力等缺陷,严重影响早产儿日后的生活质量[1]。尽管目前认为WMI是多因素作用的结果,但感染/炎症反应在脑白质损伤中的作用日益受到重 White matter injury (WMI) is the most common type of brain injury in preterm infants. In the United States, about 65,000 very low birth weight infants are born each year, with a WMI incidence of up to 50%, of which 5% to 10 % Cerebral palsy occurred, 25% ~ 50% left cognitive, behavioral, attention and other defects, seriously affecting the quality of life of premature children after the day [1]. Despite the current belief that WMI is a multifactorial result, the role of the infection / inflammation response in white matter lesions is increasingly being emphasized