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众所周知,左旋多巴治疗巴金森氏病在最初几年疗效最好,2～3年后,疗效开始降低,并出现各种付作用.而调整药物剂量和改变投药方案仅对部份患者有效,因之有人推荐“药物假日”(drug holiday).作者用此方法治疗9例严重的巴金森氏病患者,其中男性7例,女性2例,平均年龄65.8岁,发病时的平均年龄为58.6岁.患者入院时已经接受左旋多巴治疗的时间平均为5.2年,平均日剂量为Carbidopa68mg/左旋多巴680mg.“药物假日”疗法的具体步骤是:突然停用含左旋多巴的药物,在停药3～4天或8～21天后,重新开始用小剂量的左旋多巴,在几天内逐渐增加剂量.在运动不能得到缓解后,辅以理疗和职业治疗.
As we all know, levodopa treatment of Parkinson’s disease in the first few years the best effect, 2 to 3 years later, the efficacy began to decline, and a variety of pay.And adjust the dose and change the drug program is only effective in some patients, Someone therefore recommended “drug holiday.” The authors used this method to treat 9 patients with severe Parkinson’s disease, including 7 males and 2 females, with an average age of 65.8 years, with an average age of onset of 58.6 years old. Patients had already received levodopa for an average of 5.2 years on admission, with an average daily dose of Carbidopa 68 mg / levodopa 680 mg. “Drug Holiday ” The specific steps are: Suddenly disable levodopa-containing Drugs, in withdrawal 3 to 4 days or 8 to 21 days, restart with a small dose of levodopa, gradually increase the dose within a few days in the exercise can not be alleviated, supplemented by physical therapy and occupational therapy.