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乙二胺四乙酸二钠钙(CaNa_2EDTA)用于铅中毒的诊断和治疗已有多年,有人报道该药对人体肾功能有不良作用。为了证实CaNa_2EDTA 驱铅对人体肾功能是否有害,作者对122名退伍军人作了研究,以血清肌酐浓度作为肾小球渗透率的指标来检查肾功能。方法与结果:受试者平均年龄为54岁,其中有74名已出现肾功能不良(血清肌酐浓度为1.6mg/100ml 或更高),初步诊断49名为痛风,33名为原发性高血压,14名为已知病因的肾病(非痛风),其余26名为怀疑有
Calcium disodium edetate calcium (CaNa_2EDTA) for the diagnosis and treatment of lead poisoning for many years, it was reported that the drug has adverse effects on human renal function. In order to confirm whether CaNa_2EDTA lead is harmful to human renal function, we conducted a study of 122 veterans to examine renal function using serum creatinine concentration as an indicator of glomerular permeability. METHODS AND RESULTS: The average age of participants was 54 years, of whom 74 had renal dysfunction (serum creatinine concentration of 1.6 mg / 100 ml or higher), 49 were initially diagnosed as gout and 33 were of primary high Blood pressure, 14 with known causes of kidney disease (non-gout), the remaining 26 were suspected