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为探讨胃液表皮生长因子（EGF）含量变化及幽门螺杆菌（Hp）感染与胃十二指肠疾病的相关性。以幽门螺杆菌感染阳性的78例消化性溃疡和61例慢性胃炎患者为研究对象，健康人20例作对照，观察胃液EGF含量变化与胃十二指肠疾病的相关性。结果发现，消化性溃疡和慢性胃炎患者胃液EGF含量分别为175．1±103．5ng／L和240．9±182．1ng／L，明显低于正常人，511.9±54．1ng／L，（均P＜0.01）。消化性溃疡患者EGF含量明显低于慢性胃炎患者，P＜0．01。具有CagA基因的Hp感染的消化性溃疡患者EGF含量明显低于慢性胃炎组，P＜0．05。表明胃液EGF含量与Hp感染有关，尤其是具有CagA基因的幽门螺杆菌感染。
To investigate the changes of gastric fluid epidermal growth factor (EGF) content and the relationship between Helicobacter pylori (Hp) infection and gastroduodenal diseases. 78 Helicobacter pylori-positive peptic ulcer patients and 61 chronic gastritis patients were selected as subjects, and 20 healthy volunteers were used as control to observe the correlation between EGF content in gastric juice and gastroduodenal diseases. The results showed that gastric juice EGF content in patients with peptic ulcer and chronic gastritis were 175.1 ± 103.5ng / L and 240.9 ± 182.1ng / L, respectively, which were significantly lower than those in normal subjects (511.9 ± 54.1ng / L, All P <0.01). The content of EGF in patients with peptic ulcer was significantly lower than that in patients with chronic gastritis, P <0.01. EGF content of Hp-infected peptic ulcer patients with CagA gene was significantly lower than that of chronic gastritis group, P <0.05. This indicates that the gastric fluid EGF content is related to Hp infection, especially the Helicobacter pylori infection with CagA gene.