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目的研究缬沙坦和雷米普利对原发高血压患者肾脏的保护作用。方法 84例对原发高血压患者随机分为缬沙坦和雷米普利组,治疗时间为10周,观察两组患者治疗前后血压、血尿素氮(BUN)、尿白蛋白及N-乙酰基-葡萄糖苷酶(NAG)的变化。结果治疗后两组患者的血压尿白蛋白和NAG均较前明显下降(P<0.05),且两组相比比较无统计学差异(P<0.05)。结论缬沙坦和雷米普利对原发高血压患者肾脏均明显保护作用。
Objective To study the protective effects of valsartan and ramipril on the kidney in patients with essential hypertension. Methods 84 cases of primary hypertension were randomly divided into valsartan and ramipril group, the treatment time was 10 weeks, before and after treatment to observe the blood pressure, blood urea nitrogen (BUN), urinary albumin and N-acetyl Alkali-glucosidase (NAG) changes. Results After treatment, the urinary albumin and NAG of the two groups were significantly decreased (P <0.05), and there was no significant difference between the two groups (P <0.05). Conclusion Valsartan and ramipril have significant protective effects on the kidneys of patients with essential hypertension.