以3,4-二羟基-2,5-呋喃二甲酸或其二甲酯为原料,与手性氨基醇直接缩合,经一步反应合成了3个3,4-二羟基-2,5-双-[2-′(4-′-取代唑啉)]呋喃化合物,产率为90%~94%,其结构经1H NMR谱、IR谱、MS谱和元素分析测试技术得到确证;并应用这些手性双唑啉配体,初步探讨了β-萘乙酮在KBH4或NaBH4作用下的不对称还原反应。结果表明,以环己烷作溶剂,采用n(配体)∶n(还原剂)∶n(β-萘乙酮)=0.04∶1.6∶1在0℃下反应72 h,产物的ee值高达83.2%,且唑啉环上4位取代基为苄基的呋喃类双唑啉,其对映选择性优于取代基为乙基的同类配体。 With 3,4-dihydroxy-2,5-furandicarboxylic acid or its dimethyl ester as raw material, direct condensation with chiral amino alcohol, one-step synthesis of three 3,4-dihydroxy-2,5-bis - [2 - ’(4’-Substituted Oxazoline)] furan compounds were obtained in 90% ~ 94% yield. Their structures were confirmed by 1H NMR, IR, MS and elemental analysis. Chiral bis-oxazoline ligands, the asymmetric reduction of β-acetones under the action of KBH4 or NaBH4 was discussed. The results showed that the ee value of the product was as high as that of n (ligand): n (reductant): n (β-acetonaphthone) = 0.04:1.6:1 at 0 ℃ for 72 h with cyclohexane as solvent 83.2%, and furanoid oxazoline of which the 4-position substituent on the oxazoline ring is benzyl is more enantioselective than the similar ligand whose substituent is ethyl.