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目的研究在海拔4000m以上的青藏高原,个体血氧饱和度随海拔高度增加而降低的个体差异及其与高原肺水肿易感相关性。方法采用前瞻性队列研究和病例-对照相关分析策略,以年龄18～50岁,出生并长期生活在低海拔地区,初次参加青藏铁路建设的汉族男性工人为研究对象,应用指式脉冲血氧饱和度测定仪测定每个人的血氧饱和度。结果血氧饱和度随高度增加而降低的幅度存在明显个体差异,当SaO2较在海平面降低>30%时,将大大增加高原肺水肿易感性,即其危险性达到62%以上(5/8=62.5%)。结论在高原上,SaO2降低30%可作为预测高原肺水肿高危人群风险的生物学指标,具有普遍实用价值。
Aim To study the individual differences of individual oxygen saturation with altitude increasing in the Qinghai-Tibet Plateau above 4000m altitude and their correlation with susceptibility to altitude pulmonary edema. Methods A prospective cohort study and case-control analysis were conducted in Han Chinese male workers aged 18-50 years old, born and living in low altitude for a long time. The oximeter measures each person’s oxygen saturation. Results There was significant individual difference in the decrease of oxygen saturation with height. When SaO2 was lower than 30% in sea level, it would greatly increase the susceptibility to altitude pulmonary edema, ie, the risk was over 62% (5/8 = 62.5%). Conclusion The reduction of SaO2 by 30% on the plateau may be used as a biological indicator to predict the risk of high-risk patients with high-altitude pulmonary edema, which is of universal practical value.