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目的:观察低剂量敌百虫对高脂模型兔动脉粥样硬化的作用。方法:新西兰兔32只,随机分为A组:喂饲高脂高胆固醇饲料加敌百虫清晨空腹灌胃(18mg·kg~(-1)·d~(-1));B组:单纯喂饲高脂高胆固醇饲料.检测喂饲饲料前和喂饲后5周、10周、15周血清PON1、胆碱酯酶(CHE)、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、C反应蛋白(CRP)和血糖(GLU);实验第5周、第10周每组处死5只免,第15周处死全部剩余兔,取主动脉全段,苏丹Ⅳ染色,Photoshop系统测定粥样斑块面积占内膜面积的百分比;检测肝PON1活性及血管内皮依赖性舒张功能(EDRR)。结果:喂饲高脂高胆固醇后,A组和B组动物的TC、TG、HDL、LDL、CRP、GLU水平明显增高,但A、B组检测值差异无显著意义(P>0.05);血清PON_1、肝PON_1活性降低,但A组PON1活性明显低于B组(P<0.05);A组和B组动物主动脉EDRR均降低,A组EDRR降低大于B((P<0.05);喂饲高脂高胆固醇饲料各组动物主动脉均见粥样硬化斑块形成,但A组动脉粥样斑块面积/内膜面积百分比明显高于B组(P<0.05)。结论:敌百虫加速实验性高脂血症动物动脉粥样硬化斑块形成,其机制可能与降低PON1活性有关。
Objective: To observe the effect of low-dose trichlorfon on atherosclerosis in hyperlipidemic rabbits. Methods: Thirty-two New Zealand rabbits were randomly divided into group A: fed with high-fat and high cholesterol diet and trichlorfon (18 mg · kg -1 · d -1) in the morning; group B The rats were fed with high-fat and high-cholesterol diet.The levels of PON1, CHE, TG, TG and TG were measured before and 5, 10 and 15 weeks after feeding, High density lipoprotein (HDL), low density lipoprotein (LDL), C-reactive protein (CRP) and blood glucose (GLU) were measured. In the fifth week and the tenth week, The total aorta, Sudan Ⅳ staining and Photoshop system were used to determine the percentage of plaque area to endometrial area. The activity of PON1 and endothelium-dependent vasodilatation (EDRR) were measured. Results: The levels of TC, TG, HDL, LDL, CRP and GLU in group A and group B were significantly higher than those in group A and B (P> 0.05) PON1 and PON1 activity in liver decreased, but the activity of PON1 in group A was significantly lower than that in group B (P <0.05). EDRR in aorta and group B were lower than that in group B (P <0.05) Atherosclerosis plaque was formed in the aorta of high-fat and high-cholesterol diet, but the area of atherosclerotic plaque / intima in group A was significantly higher than that in group B (P0.05) .Conclusion: Trichlorfon accelerated Experimental hyperlipidemia animal atherosclerotic plaque formation, the mechanism may be related to reducing PON1 activity.