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目的:提高麻黄止嗽胶囊质量标准。方法:采用薄层色谱法鉴别制剂中细辛、五味子、川贝母、桔梗、橘红五味药材,并用高效液相色谱法测定橘红的含量。结果:建立了细辛、五味子、川贝母、桔梗、橘红五味药材的薄层色谱鉴别法,空白样品无干扰;建立了高效液相色谱法测定橘红含量的方法,橙皮苷浓度在3.03~302.80μg·ml~(-1)范围内线性关系良好,r=0.999 9,平均加样回收率为99.80%(RSD=0.49%,n=9)。结论:该质量标准具有简便、准确的优点,可有效控制该制剂的质量。
Objective: To improve the quality standard of Ephedra cezuli capsule. Methods: Identification of Asarum, Schisandra chinensis, Fritillaria cirrhosa, Campanulaceae and Tangerine herb by thin layer chromatography. The content of tangerine was determined by high performance liquid chromatography. Results: The TLC identification method of Asarum, Schisandra chinensis, Fritillaria cirrhosa, Campanulaceae and Tangerine herb was established and the blank sample was not disturbed. The method of determining the content of tangerine by high performance liquid chromatography was established. The concentration of hesperidin was between 3.03 ~ The linearity was within the range of 302.80μg · ml ~ (-1), r = 0.999 9, and the average recovery was 99.80% (RSD = 0.49%, n = 9). Conclusion: The quality standard has the advantages of simplicity and accuracy, and can effectively control the quality of the preparation.