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将某医院急诊科2013年1月至2016年6月收治的急性重度有机磷中毒患者,仅采取常规治疗的28例作为对照组(A组),剩余患者随机分为常规治疗加杂合式血液净化治疗组(B组)和常规治疗加杂合式血液净化治疗、胃肠洗消溶液鼻饲治疗组(C组),并比较三组临床疗效。结果显示,与A组比较,B组、C组患者血清胆碱酯酶上升快、呼吸衰竭、中间综合征发生率低,ICU治疗时间短,死亡率低,且C组疗效优于B组(均P<0.05),但C组与B组死亡率的差异无统计学意义。三组患者治疗3 d、5 d、10 d后APACHEⅡ评分均较治疗前下降(P<0.05),且同一治疗时间B组、C组APACHEⅡ评分均低于A组(P<0.05),C组APACHEⅡ评分低于B组(P<0.05)。提示杂合式血液净化技术联合胃肠洗消溶液治疗急性重度有机磷中毒疗效较好。
A hospital emergency department from January 2013 to June 2016 admitted patients with acute severe organophosphate poisoning, only take the routine treatment of 28 cases as a control group (A group), the remaining patients were randomly divided into conventional treatment plus hybrid blood purification The treatment group (group B) and conventional therapy plus heterozygous blood purification treatment, gastrointestinal elimination solution nasal feeding treatment group (group C), and compared the clinical efficacy of the three groups. The results showed that compared with group A, serum cholinesterase in group B and group C increased rapidly, respiratory failure, intermediate syndrome rate was low, ICU treatment time was short, mortality was low, and group C was better than group B All P <0.05), but there was no significant difference in mortality between C group and B group. APACHEⅡscores of three groups were lower than that of before treatment (P <0.05), and APACHEⅡscore of group B and C were lower than that of group A (P <0.05), and group C APACHE Ⅱ score lower than the B group (P <0.05). Prompt hybrid blood purification combined with gastrointestinal solution to treat acute severe organic phosphorus poisoning is better.