鼻内用药一般是发挥其局部治疗作用,但近代亦有通过鼻腔给药,使药物进入周身血液循环而治疗全身性疾病者(如心得安)。鼻用药及其添加剂的应用,可损害鼻粘膜的纤毛运动,使粘液毡的廓清速率减慢。由于光电记录器(PERD)的发展,在活体外可记录鸡胚的气管和人腺样体组织的纤毛摆动频率。减充血剂应用后20分钟内纤毛摆动频率减低不到50%,受损功能是可逆的。局麻药及抗组织胺剂在用药20分钟内即能抑制纤毛运动,但局麻药对其功能抑制是可逆的。多数抗生素对鼻粘膜纤毛运动影响不大,且属可 Nasal medication is generally to play its role in local treatment, but also through modern nasal administration, the drug into the whole body blood circulation and treatment of systemic diseases (such as propranolol). Nasal medication and its additives, can damage the ciliary mucosa of the mucosal movement, so that the rate of clarification of mucus felt slowed down. Due to the development of the Photoelectricity Register (PERD), the ciliary beat frequency of the trachea and human adenoid tissue of chicken embryos can be recorded in vitro. Less than 50% reduction in ciliary beat frequency within 20 minutes after decongestant application, impaired function is reversible. Local anesthetics and antihistamines can inhibit ciliary motion within 20 minutes, but local anesthetic inhibition of its function is reversible. Most antibiotics have little effect on the nasal mucociliary movement, and is