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Monolithic silica spin column extraction(MonoSpin-SPE)was developed as a simple,sensitive,and eco-friendly pretreatment method which combined with ultra-fast liquid chromatography-mass spectrometry(UFLC-MS)to determine the levels of six phthalate esters,dimethyl-(DMP),diethyl-(DEP),dipropyl-[DPrP],butyl-benzyl-(BBP),dicyclohexyl-(DcHP),and di-n-octyl-(DOP)phthalate in physiological saline samples.Under optimized experimental conditions,the method was linear in the following ranges:0.2-50 μg/L for DMP,DEP,DPrP,DcHP and DOP;5-100 μg/L for BBP.The correlation coefficients(R2)were in the range of 0.9951-0.9995 for all the analytes and the limits of detection(LODs)and limits of quantification(LOQs)were in the ranges of 0.02-0.9 μg/L and 0.08-2.7 μg/L,respectively.The pretreatment process showed good reproducibility with inter-day and intra-day relative standard deviations(RSDs)below 8.5% and 11.2%,respectively.This method was used to determine the levels of six phthalate esters in physiological saline samples and the recoveries ranged from 71.2% to 107.3%.DMP and DEP were found in actual physical saline samples(brand A and brand B).
Monolithic silica spin column extraction (MonoSpin-SPE) was developed as a simple, sensitive, and eco-friendly pretreatment method which combined with ultra-fast liquid chromatography-mass spectrometry (UFLC-MS) to determine the levels of six phthalate esters, - (DMP), diethyl- (DEP), dipropyl- [DPrP], butyl-benzyl- (BBP), dicyclohexyl- (DcHP), and di- n-octyl- (DOP) phthalate in physiological saline samples. conditions, the method was linear in the following ranges: 0.2-50 μg / L for DMP, DEP, DPrP, DcHP and DOP; 5-100 μg / L for BBP.The correlation coefficients (R2) were in the range of 0.9951- 0.9995 for all the analytes and the limits of detection (LODs) and limits of quantification (LOQs) were in the ranges of 0.02-0.9 μg / L and 0.08-2.7 μg / L, respectively. The pretreatment process showed good reproducibility with inter- day and intra-day relative standard deviations (RSDs) below 8.5% and 11.2% respectively. This method was used to determine the levels of six phthalate esters in physi The levels of saline samples and the recoveries ranged from 71.2% to 107.3%. DMP and DEP were found in actual physical saline samples (brand A and brand B).