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泊洛沙姆407(poloxamer 407,P407)是聚氧乙烯-聚氧丙烯-聚氧乙烯的三嵌段共聚物,一定浓度下的P407具有特殊的反向热胶凝性质,即低温时为液体,体温下成为原位凝胶,因具有给药便利、缓释长效、患者顺应性高等优点,该凝胶成为当前制剂研究的一大热点。现根据给药途径的不同,综述了近年来P407原位凝胶在注射、黏膜给药、经皮给药等方面的研究状况,评价了该载体应用中存在的问题,并对其前景进行了展望。
Poloxamer 407 (P407) is a triblock copolymer of polyoxyethylene-polyoxypropylene-polyoxyethylene. P407 has a specific reverse thermal gelling property at a certain concentration, that is, liquid at low temperature , Becomes the gel in situ at body temperature, and has the advantages of convenient administration, long-term sustained release and high patient compliance. The gel has become a hot spot in the research of current formulation. According to the different route of administration, the research status of P407 in situ gel in injection, mucosal administration, transdermal administration and so on are reviewed in this paper, the problems existing in the application of the carrier are evaluated, and the prospect of P407 in situ gel Outlook.