目的 :研究乙酰胡椒乙胺 (piperoethylacetylamine ,PAA)对扑热息痛 (acetaminophen ,AP)肝脏毒性的保护作用及其机制。方法 :小鼠igPAA后ipAP ,检测小鼠肝脏的损害程度 ,高效液相法检测血中AP含量 ,检测小鼠肝细胞色素P 45 0含量。结果 :PAA明显降低AP所致的小鼠血清转氨酶升高 ,减轻肝脏病理损害 ,阻止肝内谷胱甘肽下降 ,增加肝细胞色素P 45 0含量 ,血中AP浓度明显降低。结论 :PAA对AP中毒小鼠有明显肝保护作用。 Objective: To study the protective effect of piperoethylacetylamine (PAA) on liver toxicity of acetaminophen (AP) and its mechanism. Methods: The mice were killed by ipAP after igPAA, the content of AP in blood was detected by HPLC and the content of P45 0 in liver of mice was detected. Results: PAA significantly decreased the level of serum aminotransferase, reduced hepatic pathological damage, prevented the decrease of hepatic glutathione, increased the content of hepatic cytochrome P 45 0, and significantly decreased the concentration of AP in blood. Conclusion: PAA has obvious hepatic protective effect on AP poisoning mice.