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肝素钠在精制过程中,在原料含钙过量时,采取了以草酸铵除钙的方法,肝素溶液在碱性情况下乘热缓缓加入5％草酸铵,以铬黑T作为指示剂,能达到合格质量指标。肝素钠是酸性粘多糖类生化药物,过去外国药典中,仅规定作为抗凝血药物,现在它的生物活性和临床应用,已不限于此。在血管疾病的治疗方面有其特点,其他方面应用也日益增多。目前,在肝素国外对其溶解度有不同要求。有规定配成5％溶液,应全部溶解,并达到一定的澄明度。现在有些国家更要求溶解度达到40％(至少要20％)并规定40％溶液放置后不得有沉淀。
Heparin sodium in the refining process, the raw material in excess calcium, ammonium oxalate to take a method of calcium, heparin solution in the case of heat slowly by adding 5% ammonium oxalate, chrome black T as an indicator, can Achieve qualified quality indicators. Heparin sodium is an acidic mucopolysaccharide biochemical drug. In the past, only foreign pharmacopoeia was prescribed as an anticoagulant drug. Now its biological activity and clinical application have not been limited thereto. In the treatment of vascular disease has its own characteristics, other applications are also increasing. At present, the solubility of heparin in foreign countries have different requirements. There are provisions dubbed 5% solution, should be fully dissolved, and to a certain degree of clarity. Some countries now require more than 40% solubility (at least 20%) and provide 40% solution after the deposit without precipitation.